Chronic psychological stress mediated immune modulation induced autoimmune diseases

London Journal of Research in Science: Natural and Formal
Volume | Issue | Compilation
Authored by Shrihari T.G , NA
Classification: For Code: 170101
Keywords: HPA-axis, autoimmunity, neuropeptides, cortisol, NF-KB, Tregs.
Language: English

chronic psychological Stress is a main etiological factor for autoimmune diseases by releasing neuropeptides activates inflammatory mediators such as IL-1,TNF- α,IL-6, and COX-2 , proinflammatory cytokines induce activation of NF-KB a key transcription factor involved in chronic inflammation , immune modulation, cell proliferation, cell survival, angiogenesis, and augments autoimmunity. This article briefs about the role of chronic psychological stress mediated immune modulation induced autoimmune diseases.


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