Beta-endorphin is an abundant endorphin, more potent than morphine, synthesized and stored in  the anterior pituitary gland; it is a precursor of POMC (Proopiomelanocortin). Endorphins are produced during yoga, pranayama, intense physical exercise creates a psychological relaxed state known as 'Runner's high', Love, tender, care, acupuncture, music therapy, dancing, singing, mindful meditation, sex, sympathy, empathy in caring the patient(1-4).