Objectives: The aim of this study was to investigate the nutrition profile of advanced cancer patients who were admitted to specialized home palliative care. Methods: A consecutive sample of home care patients at admission of home care was assessed. Depression, anxiety, nausea, poor appetite, and poor well-being were measured by numerical scale 0-10.  Mini nutritional assessment form (MNA-SF), fatigue assessment scale (FAS), and sarcopenia bySARC-F.  were performed. The use of drugs used for anorexia, including corticosteroids, progestins, or others, was recorded. Results: Data of 135 patients were analyzed.Sixty-eight per cent and 77% of patients resulted to bee malnourished and sarcopenic. In the multivariate regression analysis, anxiety (p=0.036) and total FAS (p=0.013) were independently associated with malnutrition. Fifty-five per cent of patients were receiving corticosteroids or megestol acetate. No significant associations with parameters examined were found. Conclusion: The majority of advanced cancer patients admitted to home palliative care were malnourished independently of the primary tumor diagnosis. Indeed, fatigue and anxiety were independently associated with malnutrition