Characteristics of Oxygen-Dependent Processes in Pulmonary Tuberculosis and Their Dynamics in the Course of Complex Treatment

In conditions of tuberculous inflammation, decompensation occurs in the system of peroxidation – antioxidant protection, in which the mechanisms of oxygen transport by blood play an important role.
Many pathogenetic links in the development of tuberculosis (TB) lungs insufficiently studied, in particular, of blood oxygen carrying (OC) of blood.
Purpose of the work To determine the nature of changes in the oxygen-binding properties of blood and the main parameters of the pro-oxidant-antioxidant balance in pulmonary tuberculosis and in the conditions of complex treatment of destructive forms of pulmonary tuberculosis.
Material and methods. 120 patients with different types of pulmonary tuberculosis were examined. In the first 10 days after the patient's admission to the hospital, 10 ml of blood was taken from the ulnar vein against the background of restored outflow. OC was evaluated within one hour after venous blood sampling. The remaining part of the blood was separated by centrifugation into plasma and red blood cell mass, which were stored at a temperature of-80 ° C, followed by measurement of the pro-oxidant-antioxidant state for one month.
Then, 26 patients with various forms of destructive pulmonary tuberculosis were examined, in the treatment of which, along with standard chemotherapy, an artificial pneumothorax was used.
Results. It was found that the deterioration of blood oxygen transport function indicators occurs depending on the prevalence of the tuberculosis process and the severity of the patient's condition. High values of nitrate/nitrite concentrations are observed: in disseminated forms, they increase by 45.7% (p

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The authors declare no conflict of interest.

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The datasets used in this study are openly available at [repository link] and the source code is available on GitHub at [GitHub link].

This work did not receive any external funding.