Abstract
During the period of clinical and epidemiological study of epilepsy among the population in the Mashtaga settlement of Baku city (2017-2019), the effect of optimization of antiepileptic therapy on the course of epilepsy in patients in the region was studied.
Material and metods. The work was carried out on the basis of the United City Hospital (UCH) No. 7 of the Mashtaga village and at the Department of Neurology of the Educational – Therapeutic Corps of the Azerbaijan Medical University. Optimization of therapy was carried out with antiepileptic drugs dispensed to patients by a local polyclinic institution. The Fisher test was used to assess the qualitative parameters. Correlation analysis was carried out using Pearson’s rank correlation coefficient. The results are presented at the level of significant significance p <0.05.
Results and discussion. After optimization of patients with AE therapy, remission within 2 years was observed in 116 (58.9%) patients (χ2=1,376; p=0,012); within 6-9 months – in 42 (21.3%) patients (χ2=2,328; p=0,007); 39 (19.8%) patients had no effect (χ2=4,125; p=0,039). In the study, carbamazepine prescribed to patients with symptomatic forms of epilepsy (24 (32.8%) patients with TLE and 22 (57.9%) with FLE) as monotherapy was better tolerated. A positive effect was observed: in 8 (10.9%) patients with TLE who took carbamazepine in combination with levetiracetam; in 9 (12.3%) patients with TLE and in the same number of patients with IGE who received biterapy of carbamazepine with valproic acid; in 5 (6.8%) patients with TLE and 10 (26.3%) with FLE, who used carbamazepine with topiramate.
Conclusions. Successful optimization of antiepileptic therapy, promotion of a healthy lifestyle will be a reserve in reducing perinatal brain damage, CVP, TBI and related disability of epilepsy patients in the village, both from childhood and at working age.
Keywords