Indian scenario shows the infertility of chemical fertilizer is increasing day by day as compare to natural or bio- fertilizer so we are facing the symptoms of illness like birth defect, neurological condition like attention, deficit, hyperactivity disorder (ADHD), chlorine illnesses like diabetes and degenerative diseases like cancer also, the effect of chemical fertilizer in the farming & agriculture are very high. Farmers were happy of getting increased yield in agriculture in the beginning, but slowly chemical fertilizer started displaying their ill-effect such as: leaching out, polluting water basin, destroying micro-organisms and damaging the plant, hence reduce the crop yield, organic matter form soil leads to soil acidification also excess amount of nitrogen used in chemical fertilizer can cause to the release of greenhouse gases like carbon dioxide and nitrous oxide. Bio-fertilizers help to colonize the rhizosphere or the interior of the plant and increasing the growth of the plant by maintaining the availability of micro-organisms. The micro-organisms can regain the soil’s natural nutrient cycle and established soil biological matter. Continuous use of bio-fertilizers makes the soil rich in essential nutrients, which promotes good yield. The bio- fertilizer can be needed to reduce the use of synthetic or chemical fertilizer and pesticide. Bio-Fertilizer can be prepared by both ways in solid as well as in liquid form. This paper is underline In view of the shifting focus towards production methodology, uses as well applications of bio compost, insecticides, Germinator at homemade and also large scale production. so public awareness programmers to enhance the extra potential of sustainable agriculture development as well as encouraging private organization and policy makers to take interest in this field.