Autoimmune Responses and the Roles of Virus Infections, Complimentary Peptides, Phosphatidylserine and Physiologic Checkpoint Molecules in their Generation

When there are two complimentary peptides on the class I major histocompatibility (MHC) complexes present on a cell’s surface and the foreign peptide present on a virus binds to a complimentary peptide on the class I MHC of one of them this will produce both an adaptive, and an innate autoimmune response. The adaptive response will be to the foreign virus peptide exposed on the class I MHCs of the infected cells and the innate autoimmune response will be to the self-peptide exposed on the uninfected cells that are complimentary to the peptide the virus binds to. The cytotoxic T cells (CTLs) generated in adaptive immune responses will have peptides on their T cell receptors (TCRs) that are complimentary to the foreign peptide exposed on the class I MHC of the infected cells and to the identical self-peptides on the class I MHCs of uninfected cells.

When there are two complimentary peptides on the class I major histocompatibility (MHC)complexes present on a cell’s surface and the foreign peptide present on a virus binds to a complimentary peptide on the class I MHC of one of them and infects it this will produce both an adaptive immune response to those cells and complimentary peptides on the T cell receptors (TCRs) of the cytotoxic T cells (CTLs) generated there will bind to to the , immune response to the and an innate autoimmune response.

The adaptive response will be to the foreign virus peptide exposed on the class I MHCs of the infected cells and the innate autoimmune response will be to the self-peptide exposed on the uninfected cells that are complimentary to the peptide the virus binds to. The cytotoxic T cells (CTLs) generated in adaptive immune responses will have peptides on their T cell receptors (TCRs) that are complimentary to the foreign peptide exposed on the class I MHC of the infected cells and to the identical self-peptides on the class I MHCs of uninfected cells.

Cells are damaged in all three immune responses resulting in phosphatidylserine (PS) on their surface where it.

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The authors declare no conflict of interest.

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The datasets used in this study are openly available at [repository link] and the source code is available on GitHub at [GitHub link].

This work did not receive any external funding.