Body Weight Changes, Histological Features and Anti-Hyperglycemic Effects of Cocoyam-Soya Bean-Bambara Groundnut Flour Blend-Fed Streptozotocin (STZ)-Induced Diabetic Rats.

Background: Diabetes mellitus (DM) has a global prevalence of 536.6 million people, which an estimated rise of 12.2% by 2045. Diabetes management is expensive, hence alternate management options are being explored. The World Health Organization recognizes some plants and plant-based meals as excellent diabetes treatment agents. These include cocoyam (CYN), soya bean (SB), and Bambara groundnut (BGN). The purpose of this study was to evaluate these extracts' hypoglycemic, weight changes and histological effects.

Methodology: CYN, SB, and BGN were sourced and processed to generate high-quality flour, which were pelletized and oven-dried at 60°C, before storage. The eighty-two male albino rats weighing between 134 and 247 g, were administered with low-dose fructose to induce insulin resistance. Type 2 diabetes mellitus (T2DM) was induced with  intraperitoneal injection of streptozotocin, following which a 28 days intervention formulations were administered. Throughout the investigation, the weights of the rats were recorded while on the 28th day, their organs and blood samples were collected from killed rats for histological examination and blood glucose analysis respectively.

Results & Discussion: The investigation revealed an average random blood glucose (RBG) levels that varied significantly over time for each group, displaying a consistent pattern of changes across the entire group from week 1 to week 4 (F=79.106, p

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The authors declare no conflict of interest.

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The datasets used in this study are openly available at [repository link] and the source code is available on GitHub at [GitHub link].

This work did not receive any external funding.