Disordered Breath-Brain Lateralization: At the Core of Schizophrenia Pathogenesis

The nasal cycle rhythmic lateralization is linked to the brain's hemispheric dominance in the opposite direction. Both change in a rhythmic shift, causing parasympathetic and sympathetic states of the autonomic nervous system, which control the ergo trophic and trophotrophic BRAC (basic rest-activity cycle) phases of the body. These ultradian rhythms regulate homeostasis and catecholamine levels in human beings. Disturbed nasal cycle variation may create unbalanced functioning between both hemispheres, with one becoming hypoactive and the other becoming hyperactive, leading to neurodegeneration and neurotransmitter deregulation, thereby creating psychopathology, as in Schizophrenia

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The authors declare no conflict of interest.

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The datasets used in this study are openly available at [repository link] and the source code is available on GitHub at [GitHub link].

This work did not receive any external funding.