Effect of Four Different Classes of Artemisinin-based Combination Therapies on Antioxidant System of Malaria-Infected Albino Mice

The effect of four classes of artemisinin-based combination therapies (ACTs) on the antioxidant system of malaria-infected mice was undertaken. Thirty-six, three months old male and female albino mice weighing 25-31g were randomly divided into six groups of six mice per group. Group 1 animals served as normal control. Group 2 animals served as positive control; were infected with Plasmodium berghei without being treated with ACTs. The test groups 3, 4, 5 and 6 animals were infected with Plasmodium berghei and treated with artesunate-amodiaquine, artemether-lumefantrine, artesunate-mefloquine, and dihydroartemisinin-piperaquine phosphate respectively, at therapeutic doses. At the end of the three days treatment, the animals were sacrificed using chloroform anaesthesia and the blood samples were collected by cardiac puncture for analyses, using standard methods. Artesunate-amodiaquine indicated a significant (p

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The authors declare no conflict of interest.

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The datasets used in this study are openly available at [repository link] and the source code is available on GitHub at [GitHub link].

This work did not receive any external funding.