Neurological Manifestation of Chikungunya Virus and its Implication in the Pathogenesis of Guillain-Barré Syndrome: A Systematic Review of Clinical and Mechanistic Evidence

Chikungunya virus (CHIKV) infection has been linked to severe neurological outcomes, notably Guillain-Barré Syndrome (GBS). This systematic review highlights clinical and mechanistic evidence associating CHIKV with autoimmune polyradiculoneuropathies. Findings reveal the virus’s neurotropism and support its role as a triggering factor for GBS. Despite methodological heterogeneity among studies, the evidence underscores important implications for diagnosis, clinical surveillance, and patient management. Deeper understanding of this relationship is essential to improve preventive and therapeutic health strategies.