Oxidative Stress in Oral Mucosa Cells of Adults with Fixed Orthodontic

Objective: The aim of our study was to assess the level of cytotoxicity of orthodontic appliances by checking the hypothesis that they induce an oxidative stress in mucosal cells.

Methods: Our study included two groups: 29 controls and 34 patients undergoing orthodontic treatment with fixed appliances. Samples were collected before bonding (T0), after one month (T1), and after three months (T2) of treatment.  

Results:  Results indicate the presence of oxidative stress following bonding, with significant differences in catalase activity (p = 0.039 at T1; p = 0.01 at T2) and in SOD activity (p = 0.001  at T1 and T2). The highest levels of enzymatic activities were recorded at T1 for both enzymes but subsided at T2, suggesting cellular self-repair capabilities in response to orthodontic alloys.  

Conclusion: In view of our results, an appropriate choice of orthodontic alloys is required. Moreover, an identification of the subjects at risk for developing corrosion and galvanism and more attention are required to avoid ionic release in the oral cavity.

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The authors declare no conflict of interest.

Not applicable

The datasets used in this study are openly available at [repository link] and the source code is available on GitHub at [GitHub link].

This work did not receive any external funding.