Abstract
Enhancing patients` immune responses and antimicrobials` efficacies could overcome Antimicrobial Resistant Infections (AMR). Aluminum-magnesium silicate (AMS) is an approved Nano-stabilizing agent. Stabilizing antimicrobials prolongs time they stay at high-bioavailability and Nano-particles enhance antimicrobials` delivery to effect-targets. Prolonging high-bioavailability time and enhancing delivery to targets improve efficacies of antimicrobials while antioxidants improve immunity of patients. With improved efficacy, antimicrobials` lower dosages achieve desired effects thus avoiding side effects (immune- suppression) from high dosages. Based on these hypotheses, Medicinal synthetic AMS (MSAMS)- Streptomycin (antimicrobial-model) formulation and Vitamin C were used to treat Streptomycin- resistant Salmonella tiphymurim infections (AMR-model) in chicks (patient-models). Streptomycin`s recommended dosage (25 mg/ kg) worsened the infection, from -746.86%- reduction to -782.29 %-reduction. Stabilizing Streptomycin with MSAMS at that high dosage worsened the infection further, to -855.43 %-reduction but at 75 % dosage (18.75 mg/kg), stabilizing Streptomycin with MSAMS and supporting the treatment with Vitamin C (through feed) terminated the AMR (100 %- reduction).
Keywords