Abstract
Throughout history, the ABO system has been used as an element for clinical reasoning to analyze the relationship of different blood groups with different pathologies. There is ample evidence on the association between SARS-CoV-2 infection and polymorphism in the ABO system. Bioinformatics has revolutionized the scientific world, allowing the systematic study of biomolecules. The present work aims to clarify the relationship between the Glycosition of the SARS-COV-2 spike protein and blood groups of the ABO system, using bioinformatics tools and systematic literary review. The SARS-CoV-2 spike protein is intensely glycosylated and plays a key role in the success of viral fixation, entry and fusion of the virus membrane into host cells. The N-glycans in this protein are related to the proper folding of proteins and also to the escape of innate and adaptive immune responses. It can be seen that the glycosylation of the spike protein is extremely important for SARS-Cov-2 to perpetuate its cycle and, probably, that is the explanation of the relationship with susceptibility related to groups in the ABO system.
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