Development and Validation of Uv Spectrophotometric Estimation of Perindopril Erbumine and Indapamide in Bulk and Tablet Dosage by Using Area Under Curve Method

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Research ID 8R2CY

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Abstract

A simple, precise, accurate, and economical UV visible spectrophotometric method has been developed for estimation of Perindopril erbumine & Indapamide drug by AUC method. Quantitative determination of the drug was performed at wavelength range 208-214 nm and 239-244 nm for Perindopril erbumine & Indapamide respectively. The linearity was established over the concentration range of 10-50 µg/ml for Perindopril erbumine and 1-5 µg/ml for Indapamide with correlation coefficient value of 0.999 for both the drugs. Precision studies showed that % relative standard deviation was within range of acceptable limits. The recovery study was found to be within range of 99-101%. The proposed method has been validated as per ICH guidelines.

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Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

Not applicable

Data Availability

The datasets used in this study are openly available at [repository link] and the source code is available on GitHub at [GitHub link].

Funding

This work did not receive any external funding.

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  • Classification

    DDC Code: 610.3 LCC Code: R121

  • Version of record

    v1.0

  • Issue date

    03 February 2023

  • Language

    en

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