Abstract
The recent cancer diagnoses of King Charles and Princess Kate, while a misfortune no one wishes to happen, offer a supreme authority to rectify cancer therapies to save cancer patients. Cancer incidence and mortality continue to increase during the past 50 years. Obviously, cancer has not been eradicated. The health profession is an authoritarian profession. When the establishments at the very top of health ofessions make a mistake, there is no way to rectify the mistake, and the mistake carries on to hurt patients. It will depend on higher authorities to rectify the mistake. King Charles and Princess Kate are in such positions to force changes of current cancer therapies to save themselves and other cancer patients, many of them are in a hopeless situation created by the current therapies.
Cancer therapy has had a bad start by relying on toxic chemicals to kill cancer cells (CCs) and the disappearance of tumor as a criterion for the judgement of therapeutic efficacy. These were mistakes made by cancer establishments at a time when we did not have the complete understanding of cancer. Now we have better knowledge of cancer, but the cancer establishments are still trapped in the failed principle of killing of CCs and the disappearance of tumor to direct cancer therapies. Cancer evolves as a consequence of wound unhealing due to the collapse of chemo-surveillance. Wound healing requires the proliferation and the terminal differentiation of progenitor stem cells (PSCs). Chemo-surveillance is the nature’s creation of allosteric regulation on abnormal methylation enzymes (MEs) to achieve terminal differentiation. Abnormal MEs are also the nature’s creation to allow the buildup of PSCs to heal the wound. MEs of PSCs are abnormal due to association with telomerase. The buildup of PSCs is limited by contact inhibition. The nature does not create a mechanism to rectify the breakdown of chemo-surveillance. Inability to complete terminal differentiation of PSCs forces PSCs to evolve into cancer stem cells (CSCs) in order to escape contact inhibition. By a single hit to silence TET-1 enzyme, which is well within the reach of PSCs equipped with abnormally active MEs, PSCs can be easily turned to become CSCs. The proliferation of CSCs still cannot heal the wound, because the problem is the breakdown of chemo-surveillance. CSCs are then forced to progress to faster growing CCs by chromosomal abnormalities such as translocations to activate oncogenes or deletions to inactivate suppressor genes. Evidently, cancer evolves due to wound unhealing. Therefore, the appropriate solution of cancer is to follow the wound healing process. Pro-wound healing is the right approach of cancer therapy. Cancer establishments pursue the opposite approach by treating with toxic chemicals or agents that create more wounds to aggravate the already bad situation to result in horrendous cancer fatalities. Cancer establishments are responsible for the failure of cancer therapies. King Charles and Princess Kate are the supreme authorities to direct the right approach of cancer therapies to save themselves and other cancer patients in the same situation.
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